Methylene Tetrahydrofolate Reductase Gene Polymorphism C677T & Risk of Type two Diabetes Mellitus in Beni-Suef Governorate

Document Type : Original Article

Authors

1 Lecturer in Health Radiation Research department , National center of Radiation Research and Technology , Atomic Energy Authority

2 Internal Medicine Faculty Of Medicine Beni-Suef University

3 Lecturer of Clinical Pathology Faculty of Medicine Beni-Suef University

4 Health Radiation Research Department, Biotechnology Branch, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority.

Abstract

Background: Methylene Tetrahydrofolate Reductase (MTHFR) is known to be a regulatory enzyme of homocysteine metabolism. In many ethnic groups point mutations in MTHFR gene are implicated in the pathogenesis of diabetic nephropathy (DN) and other complications of type II diabetes mellitus (T2DM). Aim of the work: The aim of this study was to assess if MTHFR C677T gene polymorphism was one of the risk factors for the development of diabetic nephropathy as well as other complications in type 2 diabetes mellitus patients. Subjects and methods: The MTHFR C6777T polymorphisms were detected in 50 persons by PCR-RFLP. Subjects were divided into 2 groups; 30 patients with type II DM and 20 persons who were non-diabetic healthy controls. Results: The presence of MTHFR 677T allele did not increase the risk of complications in T2DM patients. The presence of mutant genotypes CT and TT did not increase the risk of nephropathy or other complications in the subjects having a C677T mutation. Conclusion: Methylene Tetrahydrofolate Reductase (MTHFR) C677T gene mutation was neither associated with an increased risk of diabetic nephropathy nor other complications of type II diabetes mellitus.

Keywords

Arab Journal of Nuclear Sciences and Applications
Volume 53, Issue 2
April 2020
Pages 159-166

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