Hassan, A., El-Sonbaty, S. (2020). Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. Arab Journal of Nuclear Sciences and Applications, 53(1), 234-242. doi: 10.21608/ajnsa.2019.66500
Asmaa Hassan; S. M. El-Sonbaty. "Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma". Arab Journal of Nuclear Sciences and Applications, 53, 1, 2020, 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. (2020). 'Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma', Arab Journal of Nuclear Sciences and Applications, 53(1), pp. 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. Arab Journal of Nuclear Sciences and Applications, 2020; 53(1): 234-242. doi: 10.21608/ajnsa.2019.66500
Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma
1Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
2Department of Radiation Microbiology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
Abstract
For many decades the terrestrial plants are represent an infinitive source of bioactive substances as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs.Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent. It also has anti-tumor activity. Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose γ-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine. Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or γ-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-α (HIF-α)and monocytichemotactic protein-1(MCP-1) were significantly decreased. Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased. Moreover, the histopathological analysis revealed that a mild improvement .In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or γ- radiation by induce apoptosis and reduce angiogenesis.
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