• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Editorial Staff
    • Publication Ethics
    • Indexing and Abstracting
    • Related Links
    • FAQ
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Reviewers
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Arab Journal of Nuclear Sciences and Applications
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 54 (2021)
Volume Volume 53 (2020)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 52 (2019)
Volume Volume 51 (2018)
Hassan, A., El-Sonbaty, S. (2020). Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. Arab Journal of Nuclear Sciences and Applications, 53(1), 234-242. doi: 10.21608/ajnsa.2019.66500
Asmaa Hassan; S. M. El-Sonbaty. "Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma". Arab Journal of Nuclear Sciences and Applications, 53, 1, 2020, 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. (2020). 'Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma', Arab Journal of Nuclear Sciences and Applications, 53(1), pp. 234-242. doi: 10.21608/ajnsa.2019.66500
Hassan, A., El-Sonbaty, S. Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma. Arab Journal of Nuclear Sciences and Applications, 2020; 53(1): 234-242. doi: 10.21608/ajnsa.2019.66500

Anticancer Activity of Fermented Solenostemm Aargel Extract and/or Low Dose Gamma Radiation Against Hepatocellular Carcinoma

Article 24, Volume 53, Issue 1, Winter 2020, Page 234-242  XML PDF (771.05 K)
Document Type: Original Article
DOI: 10.21608/ajnsa.2019.66500
Authors
Asmaa Hassan email 1; S. M. El-Sonbaty2
1Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
2Department of Radiation Microbiology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt
Abstract
For many decades the terrestrial plants are represent an infinitive source of bioactive substances  as well as pharmaceutical components which play a main role in the discovering ,developing and manufacturing of anticancer and antibiotic drugs.Solenostemmaargel is a desert plant widely used in Arabic countries as antispasmodic, anti-inflammatory and anti-rheumatic agent. It also has anti-tumor activity. Aim: the present study was oriented to investigatethe hepato-protective effect of fermentedSolenostemmaargelleave extract (100amg/kg b.wt) and/or low dose γ-radiation (0.5Gy) againsthepatocellular carcinoma (HCC)developedin rats by injection of diethylnitrosamine. Results: the data obtained revealed that thepro-apoptotic agents (caspase 3 and cytochrome c) undergoes significant elevation in HCC rats received plant extract and/or γ-radiation compared to HCC rats.While,the vascular endothelial growth factor (VEGF), hypoxia inducible factor-α (HIF-α)and monocytichemotactic protein-1(MCP-1) were significantly decreased. Also, the activity of cyclooxygenase-2 (COX-2) was significantly decreased. Moreover, the histopathological analysis revealed that a mild improvement .In conclusion, the improvement emerged in HCC rats could be attributed to the potency of extract and/or  γ- radiation by induce apoptosis and reduce angiogenesis.
Keywords
Fermented Solenostemmaargel Extract/ Low Dose γ-Radiation/HCC/ Diethylnitrosamine
Statistics
Article View: 387
PDF Download: 423
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.