The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats

Abdel-Aziz, Nahed; Badawy, Ahmad; El-Gamal, Ahmad; El-Belely, Ehab; Hammad, Aly; Zakria, Abeer

doi:10.21608/ajnsa.2022.125836.1558

The Possible Impact of Spirulina and Chlorella on some Hematological and Biochemical Aspects in Irradiated Rats

Document Type : Original Article

Authors

¹ Radiation Biology Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority Cairo, Egypt.

² Radiation Microbiology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.

³ Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.

⁴ Radiation Microbiology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt

⁵ E.A.E.A

10.21608/ajnsa.2022.125836.1558

Abstract

Background: Patients undergoing radiotherapy may suffer from many harmful effects including gut microbiota injury, therefore, the use of exogenous probiotics is suggested to reduce these effects. Aim: The present study aimed to determine the possible protective effect of Spirulina platensis and Chlorella vulgaris against radiation-induced hematological and biochemical disturbances in male albino rats. Materials and Methods: Spirulina or chlorella was administered orally at a dose level of 300 mg/kg body weight daily for one week before and one week after the exposure to gamma radiation (6Gy, single dose). Results: Whole-body gamma-irradiation induced a significant decrease in total leukocyte count, red blood cell count, hemoglobin concentration, hematocrit value and platelets count, compared to their corresponding values of the control group. A significant increase in alanine aminotransferase (ALT) activity, marker of liver damage, and a non-significant increase in urea and creatinine levels, markers of kidney function was is observed. Spirulina or chlorella administration pre- and post-irradiation has significantly attenuated the radiation-induced disturbances in the studied parameters. Conclusion: oral supplementation of spirulina or chlorella may afford protection against radiation-induced detrimental effect and may preserve the tissue integrity and the functions of different organs in the body.

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