Assessment of Framingham Risk score and Serum Leptin in Patients with Skin Tag

Abstract

Skin tags are common dermatological lesions that have been linked to metabolic syndrome, which includes diabetes, obesity, and hypertension, as well as cardiovascular disease. Increased adipose deposition and serum leptin levels may be associated with skin tags (STs). The relationship between serum lipid profile and serum leptin levels in patients with skin tags and the Framingham risk score was investigated. The Framingham risk score (FRS) is a method to calculate the likelihood of getting cardiovascular disease (CVD) during a 10-year period (CVD). The study was done on 60 participants; 30 patients with STs and 30apparently healthy as controls. Serum lipid profile and serum leptin were measured. There was Statistically significant difference of serum leptin level between skin tag (22.6±16.4 ng/ml) group and control(13.23±10.14ng/ml) and cholesterol also showing Significance between skin tag disease group (183.3±37.12 mg/dl) and control group(155.6±21.86mg/dl). Other parameters (Low Density Lipoprotein (LDL), Triglycerides (TG) and non-High-Density Lipoprotein, cholesterol (non-HDL) shows no significant difference between two groups. An assessment was done
between skin tag and Framingham risk score; we found 70% of patients are in high and moderate risk group. Our study found association between skin tag patients and Framingham risk score.