Protective Capacity of Fusarium oxysporum Extract Against Gamma Radiation. Study for Some Biochemical Parameters in Albino Male Rats

Document Type : Original Article

Authors

1 Radioisotope department Nuclear research center ,Egyptian Atomic Energy Authority

2 Radioisotope Department, Nuclear Research Center, Egyptian Atomic Energy Authority

Abstract

The present work search the protective capacity of Fusarium oxysporum phosphate buffer extract (FO) against gamma radiation (ɣ-IR) based on evaluating the changes in some blood components in rat model. The variations in haematological and pairs of biochemical parameters were determined for 40 albino male rats which divided into five groups : negative control , positive control, i.e. irradiated only , and three treated groups administrated increasing dose of (FO) after single four Gray (Gy) gamma irradiation dose. Three doses of FO extract (0.15, 0.3 and 0.6 mg/g body mass) were chosen, as protective doses, for subsequent evaluating of its antioxidant activity and ameliorating capacity toward radiation-induced oxidative stress. The changes in the chosen parameters, due to 4 Gy irradiation and then administrating the FO, were computed after 1, 2, 3 and 7 days. Total serum protein, albumin, total globulin, besides some parameters of complete blood count (CPC) were determined and the data reached were analysed to evaluate the capacity of FO to compensate the gamma irradiation injures.
The present work is assuming that: biocomponents extracted from FO fungi have a protective role against gamma radiation which can establish protocols for medical management of radiation injuries based on natural medication.

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