Anti-Tumor Effect of Green Tea Extract, Simvastatin and Gamma Radiation on Solid Tumor in Mice

Document Type : Original Article

Authors

1 Radiation Biology Department, National Center for Radiation Research and Technology

2 Egyptian Atomic Energy Authority, National Center for radiation Research and technology, Radiation Biology Department

3 Zoology department, Faculty of Science, Ain-Shams University

Abstract

The current study was conducted of six groups (n=12) to define the efficacy of epigallocatechin gallate, simvastatin and gamma radiation individually or combined together to reduce solid tumor size induced by intramuscular injection of EC cells in the right thigh of the targeted mice. Magnetic resonance imaging device 1.5 Tesla used for radiology imaging of the normal and ascites-bearing mice under anesthesia. The animals with solid tumor were followed up daily for recording deaths, tumor size, rate of inflammation and gangrene in the tumor area of hind limb. Magnetic resonance imaging showed the intraperitoneal ascites and the soft organs (liver, kidney and intestine) which were bright in the case of ascites-bearing mouse than the normal control. Triple therapy regimen significantly reduced the tumor size (662.6±12.5) compared to the positive control (825±21.8) and increased survival rate to 66.7% compared to 25% in the positive control. Triple therapy reduced the inflammation of tumor area, preventing the gangrene incidence, and showed the best value of T/C=142, ILS=42.11 and TIR %=19.6 compared to the positive control and single treatments, so it is considered as an anti-tumor regimen according to the National Cancer Institute criteria.

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